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Power, Sex, Suicide: Mitochondria and the meaning of life, by Nick Lane
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Mitochondria are tiny structures located inside our cells that carry out the essential task of producing energy for the cell. They are found in all complex living things, and in that sense, they are fundamental for driving complex life on the planet. But there is much more to them than that. Mitochondria have their own DNA, with their own small collection of genes, separate from those in the cell nucleus. It is thought that they were once bacteria living independent
lives. Their enslavement within the larger cell was a turning point in the evolution of life, enabling the development of complex organisms and, closely related, the origin of two sexes. Unlike the DNA in the nucleus, mitochondrial DNA is passed down exclusively (or almost exclusively) via the female
line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to 'Mitochondrial Eve'. Mitochondria give us important information about our evolutionary history. And that's not all. Mitochondrial genes mutate much faster than those in the nucleus because of the free radicals produced in their energy-generating role. This high mutation rate lies behind our ageing and certain congenital diseases. The latest research suggests that mitochondria play a key role in
degenerative diseases such as cancer, through their involvement in precipitating cell suicide.
Mitochondria, then, are pivotal in power, sex, and suicide. In this fascinating and thought-provoking book, Nick Lane brings together the latest research findings in this exciting field to show how our growing understanding of mitochondria is shedding light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. This understanding is of fundamental importance, both in understanding how we and all other complex life came to be, but also in order to be able to
control our own illnesses, and delay our degeneration and death.
'An extraordinary account of groundbreaking modern science... The book abounds with interesting and important ideas.'
Mark Ridley, Department of Zoology, University of Oxford
- Sales Rank: #114193 in eBooks
- Published on: 2006-10-26
- Released on: 2006-10-26
- Format: Kindle eBook
Review
"Full of fascinating insights into the origins of life."--Chemistry World
"Full of startling insights into the nature and evolution of life as we know it."--The Economist
Review
"Full of fascinating insights into the origins of life."--Chemistry World
"Full of startling insights into the nature and evolution of life as we know it."--The Economist
About the Author
Nick Lane is an honorary Research Fellow at University College London and Strategic Director at Adelphi Medi Cine, a medical multimedia company based in London. He is the author of Oxygen: The Molecule that Made the World and his writings have appeared in numerous scientific publications, including Scientific American, The Lancet, and the British Medical Journal. He lives in the UK.
Most helpful customer reviews
3 of 3 people found the following review helpful.
Now, I truly am in love with biochemistry.
By Dario Gerussi
[[VIDEOID:659c2f070076155042e3abd6c5afdbc5]] I went into this book assuming I was going to learn a lot about mitochondria given that it's a 300+ page book written by a biochemist. That definitely did happen. But what I wasn't expecting was such a rich dive into the history and culture of the science and scientists behind all these discoveries.
This was a complete journey through the scientific discoveries related to mitochondria and their vital role in the evolution of eukaryotes. Nick Lane brought up historical events within the scientific community, went over basic biochemistry, and gave his views on a number of occasions. In my opinion, it is layperson friendly - even though it gets deep into the science, Nick doesn't get too technical but does explain everything so clearly. Remembering some of the basics from biology and chemistry is all that's needed to enjoy this book.
This book was a life changing experience for me not because I learned a lot, which I did, but because of the sheer passion that Nick has for discovering the origins of complex, intelligent life.
2 of 2 people found the following review helpful.
There is more to it than natural selection
By Patrick Loughlin
While the author may not have all the answers, the questions he asks are right on, and he makes a very good attempt at answering them. Questions like: Why don't bacteria get any larger? How did organized cell suicide (apoptosis) evolve in multi-celled organisms. Why do multi-celled organisms reproduce sexually? Why do we die of old age?
Bacteria/Mitocohonria/Cloroplasts are all limited in size by the physical properties of how they generate energy: the proton pump. Mitochondria must have their own DNA. So evolution in eukaryotes is a symbiotic tension between the nucleus and the mitochondria.
All this stuff was new to me and I found it fascinating. One area I would like to find out more about is why mitochondria must have their own DNA. The author's argument is that the mitochondria need DNA in order to rapidly respond to problems in the reparation chain. Since there are many mitochondria in a cell and only one nucleus, the nucleus is too centralized to deal with different problems in each individual mitochondria. This explanation to me seems somewhat wanting. Seems like if there were a way for the DNA to be centralized in the nucleus, nature would have done it, even if was complicated.
10 of 10 people found the following review helpful.
One of the very best biology books
By Roy Marsten
This is an earlier book (2005) by the author of "Life Ascending" (2009). I read it because I liked "Life Ascending" so much. This one expands on the role of mitochondria, and is full of amazing stuff I didn't know. I read a lot of biology, evolution, and genetics and this is definitely one of the very best. Lane keeps up with the very latest research, which I wouldn't be able to understand, and weaves it into a coherent story of our best current understanding of what life is and how it works. Highest recommendation. I have just started reading his even earlier book "Oxygen" (2002).
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